iOnctura BV, headquartered in Geneva, Switzerland, was founded in June 2017 as a spin out from Merck and funded by M Ventures. It is a clinical stage biotechnology company developing a pipeline of next generation, differentiated molecules that are at the forefront of pioneering new therapies for the treatment of cancer. Each of iOnctura’s programs harness the combined effect of immune-mediated and direct anti-tumour activity and aim to deliver molecules with superior clinical efficacy and safety in oncology. The company’s lead program, IOA-244, will enter the clinic in Q1 2020. The study is aimed to clinically demonstrate for the first time that a highly selective PI3Kδ inhibition not only drives an immune-mediated response but also a direct anti-tumoural effect in a stratified patient population across multiple solid tumour indications. The Company’s second molecule is a novel autotaxin (ATX) inhibitor at IND stage for patients with solid tumours burdened with cancer-associated fibrosis. For more information, please visit www.ionctura.com

Founded in 2012, Cashforce products help large enterprises with getting more accurate cash flow forecasts and with managing working capital at a company-wide level while also providing granular insights down to the transaction level by integrating with existing ERP and TMS implementations.

Urban Sports Club offers a flexible flat-rate sports membership. The mission is to help people lead a healthy and active lifestyle. Club members can choose from 50+ activities – ranging from classic gym workout, swimming, yoga, or bouldering, to team sports and lots more – and more than 7,000 partner venues in Germany, France, Italy, Spain and Portugal. Variety, flexible conditions as well as team sports and wellness are offered both for private customers and companies. Urban Sports GmbH was founded in 2012 by Moritz Kreppel and Benjamin Roth in Berlin, Germany. After two years of bootstrapping, the company secured an early-stage financing in 2015 and went on to acquire four of its German competitors. In December 2016, the former competitor Somuchmore joined the German market leader; FITrate joined in January 2018 and in December INTERFIT.

Maximum Liquidity with Minimal Disclosure. Provable labs applies secrecy-preserving, secure multi-party computation technology to build trading platforms that allow participants to express their positions and find liquidity without the risk of price slippage.

CoEnzyme A (CoA) is essential to numerous cellular processes including the metabolism of fatty acids, amino acids and sugars, the regulation of gene expression, and the proper functioning of the TCA cycle and mitochondrial health, which generates the energy all cells need to live. There are many genetic, rare metabolic disorders that are CoA related. In addition, dysregulated CoA metabolism is a key factor in diseases as diverse as cancer, fatty liver and neurological disorders. While CoA has been in biochemistry textbooks for 70 years, there are no therapies to restore dysregulated coenzyme A metabolism. Comet Therapeutics addresses these profound unmet medical needs with its CoEnzyme Metabolism (CoMET™) Platform.

Calypso Biotech is an immunotherapy biotech company, spin-off from Merck Serono, that discovers and develops monoclonal antibodies for the treatment of immune pathologies with large unmet medical needs. Calypso Biotech’s lead program, CALY-002, is a best-in-class therapeutic antibody against interleukin-15 (IL-15).

Aidence is a company that is bringing the full potential of Artificial Intelligence into the hands of medical professionals in medical imaging and disease detection. Aidence combines data scientists, deep-learning developers and radiologists. The first product of Aidence is the AI platform Veye, a highly accurate and clinically approved assistant for medical image analysis.

Founded in 2015, Polarsteps is used by over 1 million travelers in 180+ countries to track their trips and share them in real time with their closest friends and family. Polarsteps wants to inspire and connect people through travel. It believes that the best way to do that is by creating a place where the entire travel experience is combined within one platform. From the very first inspiration on where to go, to remembering your trip years after it has ended. The Amsterdam-based startup is therefore building the place to go to for travelers that want to plan, track and remember their adventures around the globe.

Castor is a medical software development company based in Amsterdam, the Netherlands. Founded in 2011 by Derk Arts, their signature programme is a cloud-based electronic data capture platform which enables researchers to easily capture high-quality, reusable medical data. Now with 30k+ users, 2,500+ studies, servers in 3 countries and funding by INKEF Capital, Castor is well on their way to getting their platform used by medical researchers and institutions worldwide.

NMD Pharma is a small molecule drug discovery company that develops novel treatments of neuromuscular disorders. Research by the founders working on the neuromuscular junction identified an approach that improves neuromuscular transmission in a way that is potentially applicable to a range of clinical indications and orphan human diseases that have profound unmet medical need.

Founded in 2012 OneFit offers a market-leading subscription service that allows users to attend any local fitness class or gym for a flat monthly fee. Users have access to the largest network of boutique gyms and studios in the Netherlands. More than 15,000 yoga, spinning, pilates, kickboxing, crossfit, fitness classes and many others are bookable on a weekly basis through a unique one-click experience. OneFit members join these group workouts or check in for individual training at over 600 different studios and gyms. OneFit has been experiencing significant traction and is on its way to European category leadership.

NightBalance is a medical device company founded in 2009 and based in Delft, the Netherlands. The company develops and commercializes the Sleep Position Trainer, a proprietary, highly advanced and easy to use device to treat positional obstructive sleep apnea.

Withlocals is an online marketplace for travelers and locals to connect. The platform lets locals create personal and unique travel experiences for travelers, earn their fair share by doing what they love, and gives travelers authentic experiences and stories to share with their friends and families. All this while changing minds and hearts along the way.

GTX medical develops Targeted Epidural Spinal Stimulation (TESS), a unique and novel therapy for improved rehabilitation of patients suffering from spinal-cord injuries. The company is based in Eindhoven and Lausanne and uses an Implantable Neuro-stimulation System (INS) that provides for electrical stimulation of specific areas of the spinal cord with the objective to regain mobility of the lower limbs.

Bloomon, is a subscription-based flower delivery service based in Amsterdam, was founded in 2014 by Patrick Hurenkamp and Koen Thijssen. Dubbed as the ‘Netflix of Flowers’ by the Financial Times, Bloomon’s goal is to bring bespoke bouquets from grower to consumer in the fastest way possible by cutting out the traditional supply chain. Headquartered in Amsterdam, it now has international offices in Berlin, London and Taiwan.

EclecticIQ’s mission is to restore balance in the fight against cyber adversaries. Its flagship product EclecticIQ Threat Intelligence Platform enables operationalization of security information exchange, empowers collaborative analyst workflow and ensures timely integration of cyber threat intelligence detection, prevention and response capabilities. EclecticIQ applies best practices from the intelligence world in a cybersecurity setting and is currently selling to large enterprises and MSSPs.

Co-founded in 2014 by Teun van den Dries (CEO) and Sander Mulders (CTO), GeoPhy provides data-driven valuations and analytics for commercial real estate (CRE). The platform uses supervised machine learning and big data to create insights that help drive acquisition due diligence, portfolio monitoring, and site selection for institutional lenders and investors in the real estate and financial sector. GeoPhy is headquartered in Delft, the Netherlands, with offices in New York, London and Kaunas (Lithuania).

ViCentra has developed an insulin pump for diabetes patients. The company aims to create a user-friendly device designed to provide diabetes patients with greater freedom in their day-to-day lives.

Blendle wants to make the best journalism accessible to anyone, anywhere, anytime. Users have access to a personalized news offering from premium publishers, and can either pay per article or through a unique subscription. The Dutch start-up was founded two and a half years ago and now has over 1,000,000 users, the majority of them aged under 35. Blendle currently has more than 80 employees, including 15 journalists. In addition to Inkef Capital, media companies The New York Times Company, Nikkei/Financial Times and Axel Springer are among its investors.

Founded in 2011, Sapiens is a Dutch developer of deep brain stimulation (DBS) technologies, an advanced treatment that targets degenerative or functional brain disorders such as Parkinson’s disease and dystonia. With offices in Eindhoven, the Netherlands and Munich, Germany, the company’s high-resolution probe reduces stimulation-induced side effects by precisely steering the tiny stimulation currents to the intended target area. Products like SureSuite®, SurePlan®, SurePlace® and SureTune® provide an integrated, image-based solution for planning and programming optimal DBS treatment. SureStim®, the Sapiens implant, is MRI-conditionally safe, and controls the steering.

Wercker is a continuous delivery platform focusing on changing the way developers build and deploy their applications. Our platform was built in order to make developers’ lives easier and enabling them to move fast and make things. Team wercker consists of engineers and designers who have previously worked on OpenStack, Google AppEngine, Simple, Digg and Disqus with offices in Amsterdam and San Francisco

ProFibrix is a Dutch biotech company that creates, develops, and markets products for the haemostasis and regenerative medicine markets. It offers its products based on human fibrinogen, a natural blood protein for haemostasis, blood clotting and tissue repair and healing. Its main product is Fibrocaps™, a ready-to-use haemostat and tissue sealant that stop acute and severe bleeding during surgery.

GitLab Inc. is a company based on the GitLab open-source project. GitLab is an application to code, test, and deploy code together. It provides Git repository management with fine grained access controls, code reviews, issue tracking, activity feeds, wikis, and continuous integration.

Shapeways is the world’s leading 3D printing service and marketplace, empowering designers to bring amazing products to life. By giving anyone the ability to quickly and affordably turn ideas from digital designs into real products, Shapeways is fundamentally changing how products are made and by whom. Headquartered in Manhattan, Shapeways also has factories and offices in Eindhoven, Long Island City and Seattle.

Lanthio Pharma is a Dutch biopharmaceutical company committed to developing and commercializing lanthipeptides as innovative drugs for treating medical conditions. One lanthipeptide has already been out-licensed and several others are in earlier development and discovery stages for important medical indications like fibrosis and cardiovascular diseases.

Scenic Biotech BV is a spinout company of the Netherlands Cancer Institute (NKI) and Oxford University, based in Amsterdam, The Netherlands. It is Scenic Biotech’s mission to harness genetic modifiers to combat disease. The company was founded by Prof Thijn Brummelkamp and Prof Sebastian Nijman.

NPEX is a fully licensed SME-Exchange in the Netherlands. Unlike traditional exchanges, this auction-based platform enables investors to set a minimum ask price and define the time limits for the bidding process. NPEX focuses on small and medium-sized enterprises looking for growth capital of € 500,000 and higher.

Robin – short for Radar Observation of Bird INtensity” – develops innovative radar systems for tracking and identifying birds. With unique access to the world’s most advanced bird radar technology, Robin radar aims to increase flight safety for humans, bats and birds.

Audion Therapeutics is a private biopharmaceutical company dedicated to the discovery, development and commercialization of drugs and delivery technologies for the treatment of hearing loss.

InteRNA is a Dutch biotechnology company specializing in the development of RNA therapeutics for the treatment of cancer. InteRNA is a true pioneer in the discovery and creation of a new class of drugs, called microRNAs (miRNAs). The company proprietary technology platform has been developed for discovery and validation of miRNA-based drug candidates for the simultaneous regulation of multiple targets.

Corporis Medical manufacturers so-called ‘APM devices’, a revolutionary new blood-flow measuring device for bowel cancer surgery. After the bowel is removed, surgeons create a new bowel connection, called ‘the anastomosis’. This anastomosis is prone for leakage & complications if inadequately supplied of oxygenated blood. The APM device measures blood flow at the anastomosis in a revolutionary new way during surgery. Preventing these complications of the anastomosis will decrease postoperative deaths, intensive care stay & cost.

Aito is a user interface innovator that believes “a product is desirable when its interaction is pleasurable.” Headquartered in Amsterdam with a Research Department in Helsinki, Aito’ breakthrough piezoelectric sensing technology is well on its way to becoming the leader in premium user interfaces. Aito’s products are currently licensed worldwide, with a strong focus in Asia.

Crowdynews is a social media curation platform that gathers and filters relevant social media content and posts it real time next to topical, popular stories. The service provides publishing organizations with new revenue streams and augments content with social media sources such as Twitter, Facebook, YouTube, Instagram and Vimeo. The application is available in 25 languages and is active globally with offices in Groningen, Boston and Singapore.